I use Open DNS myself. Even on some work machines. Now we will have to see which is better I guess.
I am a huge Google fan, I really am, but I am starting to worry that they are doing a bit to much of "the everything".... maybe it is just me....
The big difference is OpenDNS is trying to make money where as Google is free. The other difference is a bad domain in OpenDNS will redirect to ads to try to make money where as Google will return the correct NXDomain as required by the DNS standard.
And say what you will, Google system Engineers rock. Those guy squeeze so much performance out of their systems, it's nuts.
The article I read said 4.2.2.2 and 4.2.2.1 were faster as well. I already use them, so I'll still with it.
Doc, it won't affect things like playing on a game server. It's all IP based. I doubt any games won't DNS look ups as it increases latency if used at a greater scale.
Steam uses some DNS look ups for certain things and you can use DNS to join a game server, but after that, it's all IP, no DNS.